The literature references were researched by us with the utmost care. Nevertheless, we assume no liability for the completeness and timeliness of the study information. Many of the treatment options mentioned in the product information are based on findings obtained from animal or human cell cultures, animal studies, observational studies, and to a lesser extent, randomized controlled trials (RCTs).
The evidence base for complementary medicines is continuously evolving, which can partly lead to different results. We therefore recommend that practitioners always carefully review the current evidence before using such preparations.
1) Gröber, U. 2008. Orthomolecular Medicine. A Guide for Pharmacists and Physicians
2) Gröber U. 2010. Micronutrients – Metabolic Tuning-Prevention-Therapy. Wissenschaftliche Verlagsgesellschaft
3) Böhm U, Muss C, Pfisterer M. Rational Diagnostics in Orthomolecular Medicine – Optimal Therapy through Individual Diagnostics. Hippokrates, 2004
4) Burgerstein, L. 2023. Handbook of Nutrients
5) Stossier H, Stossier G. Practical Handbook of Orthomolecular Medicine. Verlagshaus der Ärzte, 2023
6) Schmidt N, Schimdt E. Micronutrient Therapy. Urban & Fischer Verlag, 2022
7) Schmidbauer C, Hofstätter G. Micronutrient Coach – The Comprehensive BIOGENA Compendium of Nutrients. Verlagshaus der Ärzte, 2018
8) Gabriela D Colpo, Marion Leboyer, Robert Dantzer, Mahdukar H Trivedi, Antonio L Teixeira, Immune-based strategies for mood disorders: facts and challenges, Expert Rev Neurother., 2018, 18(2):139-152
9) Hüseyin Aydın, Yusuf Kenan Tekin, İlhan Korkmaz, Gülaçan Tekin, Sefa Yurtbay, Sami Keleş, Nezih Hekim, Glutamine-Driven Metabolic Adaptation to COVID-19 Infection, Indian J Clin Biochem., 2023, 38(1):83-93
10) Makoto Bannai, Nobuhiro Kawai, New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep, J Pharmacol Sci., 2012, 118(2):145-8
11) J C Hall, Glycine, JPEN J Parenter Enteral Nutr., 1998, 22(6):393-8
12) Changsong Gu, Xiangbing Mao, Daiwen Chen, Bing Yu, Qing Yang, Isoleucine Plays an Important Role for Maintaining Immune Function, Curr Protein Pept Sci., 2019, 20(7):644-651
13) Cunxi Nie, Ting He, Wenju Zhang, Guolong Zhang, Xi Ma, Branched Chain Amino Acids: Beyond Nutrition Metabolism, Int J Mol Sci., 2018, 19(4):954
14) Zachary Bloomgarden, Diabetes and branched-chain amino acids: What is the link?, J Diabetes, 2018, 10(5):350-352
15) Daniela Maria Tanase, Emilia Valasciuc, Claudia Florida Costea, Dragos Viorel Scripcariu, Anca Ouatu, Loredana Liliana Hurjui, Claudia Cristina Tarniceriu, Diana Elena Floria, Manuela Ciocoiu, Livia Genoveva Baroi, Mariana Floria, Duality of Branched-Chain Amino Acids in Chronic Cardiovascular Disease: Potential Biomarkers versus Active Pathophysiological Promoters, Nutrients, 2024, 16(12):1972
16) F A Tomblin Jr, K H Lucas, Lysine for management of herpes labialis, Am J Health Syst Pharm., 2001, 58(4):298-300, 304
17) Carla Wunderle, Luana Haller, Rahel Laager, Luca Bernasconi, Peter Neyer, Franziska Stumpf, Pascal Tribolet, Zeno Stanga, Beat Mueller, Philipp Schuetz, The Association of the Essential Amino Acids Lysine, Methionine, and Threonine with Clinical Outcomes in Patients at Nutritional Risk: Secondary Analysis of a Randomized Clinical Trial, Nutrients., 2024, 16(16):2608
18) Guoqing Wu, Jingxuan Xu, Qiyao Wang, Ziyang Fang, Yucheng Fang, Yujie Jiang, Xiaohong Zhang, Xiangrong Cheng, Jin Sun, Guowei Le, Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases, J Agric Food Chem., 2023, 71(1):5-19
19) Takuya Yoshida, Sachika Kakizawa, Yuri Totsuka, Miho Sugimoto, Shinji Miura, Hiromichi Kumagai, Effect of endurance training and branched-chain amino acids on the signaling for muscle protein synthesis in CKD model rats fed a low-protein diet, Am J Physiol Renal Physiol, 2017, 313(3):F805-F814