Positive Effects:
- Glutathione is a sulfur-containing tripeptide composed of L-glutamic acid, L-cysteine, and glycine. It is formed in the liver in a magnesium-dependent manner. It is present in every cell of the body and is predominantly intracellular. The highest glutathione concentrations are found in liver cells, erythrocytes, and immune cells.
- Reduced glutathione (GSH) is the most potent natural antioxidant in the body, which either alone or in conjunction with enzymes, reduces superoxide radicals, hydroxyl radicals, and peroxynitrites.
- GSH reactivates spent antioxidants, protects mitochondria from oxidative damage, and stabilizes mitochondrial function. In addition to this antioxidant role, glutathione is involved in many other metabolic pathways.
- GSH has an immunomodulatory effect in both Th1 and Th2 dominance. GSH inhibits the activation of NF-kB.
- GSH is antivirally effective in high doses (40–60 mg/kg BW).
- It is one of the most important nutrients for phase II liver detoxification.
- Elevated cholesterol levels and the accumulation of cholesterol in the mitochondria reduce glutathione transport systems in liver cells. Mitochondrial glutathione levels fall, leading to mitochondrial dysfunctions that can be causal for, e.g., steatohepatitis, carcinogenesis, or Alzheimer's.
- Glutathione has antioxidant, anti-inflammatory, mitotropic, neuroregenerative, anti-autoimmune, antiviral, and detoxifying effects.
- It has long been observed that environmental toxins and electrosmog shift the balance from reduced to oxidized glutathione.
Therapy Recommendations:There is evidence that the properties of the substances contained in the product can have a positive effect on health disorders of the mentioned indications:
- for xenobiotic and heavy metal exposure, to support liver function, improve chemical intolerance
- for mitochondriopathy, reduced glutathione injection improves oxygen and energy supply, protects cell and mitochondrial membranes from free radicals and ROS
- for chronic stress-related illnesses, including thyroid diseases, adrenal insufficiency
- for exhaustion and CFS
- for brain fog in combination with vitamin C 5g (administer sequentially)
- for acute and chronic infections, including neuroborreliosis
- for viral infections
- for inflammatory processes, including Crohn's disease, ulcerative colitis, celiac disease, Lyme borreliosis
- for neuroinflammation, for regeneration of the blood-brain barrier
- for neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis
- for type 2 diabetes mellitus, obesity
- for cardiovascular diseases, circulatory disorders, arteriosclerosis (heart attack, stroke)
- for autoimmune diseases, including Hashimoto's thyroiditis, Rheumatoid Arthritis, Systemic Lupus Erythematosus (SLE)
- for gingivitis, acne, asthma, allergies, COPD, autism, and bipolar disorders
- for eye functional disorders due to oxidative damage, macular degeneration, cataracts
- for erectile dysfunction
- for infertility
- for degenerative aging processes
- for glutathione deficiency in old age, which leads to a functional shift from Th1 to Th2 type
Contraindications:Do not use in children under 6 years of age. For impaired kidney, liver, or heart function, and in cases of albumin deficiency, an adjustment of the individual dose is recommended. Patients taking beta-blockers have an increased risk of decompensated cardiovascular reaction, as beta-blockers inhibit the action of adrenaline (emergency medical treatment). Patients with a tendency to allergic reactions and/or with diseases based on histamine release (e.g., asthma) should be questioned about known allergens according to the principles of therapeutic due diligence.
Contraindication:Numerous studies have shown that a loss of intracellular glutathione makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. It appears to be established that glutathione depletion improves the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy.
Cancer patients often take glutathione to reduce the toxic effects of cancer treatments and prevent damage to normal tissue. Older studies support this assumption. However, more recent studies find no scientific evidence of efficacy in reducing toxicity, except in the case of cisplatin-induced neurotoxicity.
TIP:Important co-factors in glutathione metabolism are Vitamin C, Vitamin B2, Vitamin B3, Selenium.
Note for Doctors and Therapists:In principle, for individual prescriptions, the doctor/therapist determines the indication. The suggestion is merely a recommendation for a therapy option, with the dosage and frequency of application being solely at the discretion of the doctor/therapist. The treating therapist is responsible for the treatment and must individually review and assess the respective application for each patient before starting treatment.
