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L-Methionine 2 g
L-Methionine 2 g

L-Methionine 2 g

Incl. VAT

Prescription

Dosage form: 50 ml infusion concentrate

Composition: L-methionine, citrate-phosphate buffer, water for injection

Prescription status: prescription only

Storage: store at room temperature

Shelf life: 1 year after manufacture

After completing your order, you will receive a link through which you can securely upload your prescription.
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PRODUCT INFORMATION

Composition: 

  • L-methionine 2000 mg 
  • Citric acid phosphate buffer 
  • Water for injection up to 50 ml 

Administration: i.v., always prepare the infusion solution freshly dilute as a single infusion in 100 ml of 0.9% NaCl 

Infusion set: Intrafix © Air P 

Infusion duration: 30 minutes 

Treatment interval: Once a week, based on the patient's health status 

Duration of treatment: 6 weeks, based on the patient's health status 

Storage: 15–25°C 

Shelf life: 1 year after manufacture

Side effects: Discomfort may occur in cases of impaired sulfur metabolism. Methionine may exacerbate metabolic acidosis. 
THERAPY RECOMMENDATION

Positive Effects:

  • L-methionine is an essential, sulfur-containing amino acid.
  • L-methionine serves as a sulfur donor and is the precursor of L-cysteine and L-glutathione, a sulfur-containing antioxidant.
  • The active form S-adenosyl-methionine (SAM), the most important methyl group donor in cell metabolism, is formed from methionine.
  • L-methionine is one of the limiting amino acids and plays an important role in the formation of L-carnitine, creatine, L-histidine, taurine, glutathione, choline, proteins, nucleic acids, phospholipids, neurotransmitters (adrenaline), and melatonin, among others.
  • Creatine is formed from L-arginine, L-methionine, and glycine.

Therapeutic Recommendations:There is evidence that the properties of the substances contained in the product may have a positive effect on health disorders in the mentioned indications:

  • Sports:Parenteral methionine, as well as arginine, lysine, and ornithine, induce GH secretion and promote muscle growth.
  • Liver Detoxification:Nutrient for Phase II, detoxification of xenobiotics, lead, histamine, ammonia.
  • Fatty Liver:Prevents excessive fat accumulation in the liver.
  • Liver Regeneration
  • Inflammatory arthritis, fibromyalgia
  • Exhaustion, burnout syndrome, depressive moods, anxieties
  • CNS: Stabilization of membrane fluidity similar to DHA
  • Indirect increase in cardiac performance
  • Cystitis:Acidification of urine, reduction of bacterial growth in the bladder.
  • Allergy, MCAS:L-methionine methylates histamine; histamine-allergic reactions can be "slowed down".

Contraindications:Do not use in children under 6 years of age. For impaired kidney, liver, or heart function, and in cases of albumin deficiency, an adjustment of the individual dose is recommended. Patients taking beta-blockers have an increased risk of a decompensated cardiovascular reaction, as beta-blockers inhibit the effect of adrenaline (emergency medical treatment). Patients with a tendency to allergic reactions and/or diseases based on histamine release (e.g., asthma) should be questioned about known allergens according to the principles of therapeutic due diligence.

Contraindications:High homocysteine levels. In these cases, ensure adequate supplementation of activated vitamin B2, B6, B12, and folic acid or use trimethylglycine.

Interactions:When taking antibiotics (including ampicillin, sulfonamides, nitrofurantoin), increased renal reabsorption may lead to an intensification of effects. When taking levodopa, the effectiveness of levodopa may be impaired.

CAUTION:In Parkinson's patients.

Note for Doctors and Therapists:For individual prescriptions, the doctor/therapist fundamentally determines the indication. The suggestion is merely a recommendation for a therapy option, with the dosage and frequency of application being solely at the discretion of the doctor/therapist. The treating therapist is responsible for the treatment and must individually review and assess each application for each patient before starting treatment.
Shipping Information

NATIONAL:

  • Standard shipping: €9.95 incl. VAT
  • Free shipping on orders over €200.00 (does not apply to refrigerated goods and express shipments)
  • Refrigerated and express shipping: €25.95 incl. VAT

Note: If individual products are unavailable, partial deliveries may occur, incurring no additional shipping costs.
Any requested partial deliveries will be charged.

WITHIN THE EU:
For shipments to countries in EU Zone 1, we charge logistics costs of €75.00 (incl. VAT).

For shipments to countries in EU Zone 2, we charge logistics costs of €105.00 (incl. VAT).

THIRD COUNTRIES:
The customer is asked to inquire about the logistics costs incurred for the respective country.
References

We have researched the literature with the greatest possible care. Nevertheless, we assume no liability for the completeness and topicality of the study information. Many of the therapy options mentioned in the product information are based on findings obtained from animal or human cell cultures, animal experiments, observational studies, and to a lesser extent, randomized controlled trials (RCTs).
The study situation regarding complementary medicines is subject to continuous development, which can sometimes lead to different results. We therefore recommend that therapists always carefully review the current study situation before using such preparations.

  1. Gröber, U. 2008. Orthomolecular Medicine. A Guide for Pharmacists and Physicians
  2. Gröber U. Micronutrients – Metabolic Tuning-Prevention-Therapy. Wissenschaftliche Verlagsgesellschaft, Stuttgart 2010
  3. Böhm U, Muss C, Pfisterer M. Rational Diagnostics in Orthomolecular Medicine – Optimal Therapy through Individual Diagnostics. Hippokrates, 2004
  4. Burgerstein, L. 2023. Handbook of Nutrients
  5. Stossier H, Stossier G. Practical Handbook of Orthomolecular Medicine. Verlagshaus der Ärzte, 2023
  6. Schmidt N, Schimdt E. Micronutrient Therapy. Urban & Fischer Verlag, 2022
  7. Schmidbauer C, Hofstätter G. Micronutrient Coach – The Great BIOGENA Compendium of Nutrients. Verlagshaus der Ärzte, 2018
  8. B Ditscheid, R Fünfstück, M Busch, R Schubert, J Gerth, G Jahreis, Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study, Eur J Clin Nutr., 2005, 59(6):768-75
  9. J Bellone, G Farello, E Bartolotta, G Aimaretti, S Bellone, M Mucci, F De Matteis, E Ghigo, Methionine potentiates both basal and GHRH-induced GH secretion in children, Clin Endocrinol (Oxf.), 1997, 47(1):61-4
  10. Johanna O Zeitz, Susanne Kaltenböck, Erika Most, Klaus Eder, Effects of L-methionine on performance, gut morphology and antioxidant status in gut and liver of piglets in relation to DL-methionine, J Anim Physiol Anim Nutr (Berl.), 2019, 103(1):242-250
  11. Umashanker Navik, Vaibhav G Sheth, Shaheen Wasil Kabeer, Kulbhushan Tikoo, Dietary Supplementation of Methyl Donor l-Methionine Alters Epigenetic Modification in Type 2 Diabetes, Mol Nutr Food Res., 2019, 63(23):e1801401
  12. Sharma S, Litonjua A. Asthma, Allergy, and Responses to Methyl Donor Supplements and Nutrients, J Allergy Clin Immunol., 2014;133(5):1246-1254
  13. C.G. Schwab, Limiting amino acids are essential amino acids in digested protein that are in shortest supply relative to body requirements for absorbed amino acids., Encyclopedia of Dairy Sciences, 2002